Xerra™ – Cryo-fluorescence tomography
EMIT Imaging’s flagship platform fully automates the CFT workflow: 3D visualisation of drug biodistribution and protein expression across whole organisms, at high resolution and high sensitivity.
One system, one automated workflow.
Cryo-fluorescence tomography is an ex-vivo, volumetric tissue imaging technique: white-light images provide the anatomy, fluorescence shows the labelled compound, and both are reconstructed into a single whole-body 3D dataset. Xerra automates this workflow end to end, so preclinical teams can process samples in their own lab.
Prepare & freeze
The specimen is prepared and frozen; no clearing or slide preparation is required.
Automated imaging
Xerra images the sample layer by layer: white light for anatomy, fluorescence for the labelled compound.
3D reconstruction
The stack becomes a volumetric dataset showing biodistribution and protein expression in anatomical context.
Between in-vivo imaging and histology.
In-vivo imaging
- Whole-body view of the living animal
- Longitudinal studies over time
- Limited spatial resolution
- Limited molecular specificity
Cryo-fluorescence tomography
- Whole-body 3D at high resolution
- Fluorescence signal in full anatomical context
- High sensitivity, multiplexed channels
- One fully automated workflow
Histology
- Cellular and molecular detail
- Thin 2D sections only
- No whole-body context
- Manual, labour-intensive workflow
Where CFT makes the difference.
Fields in which EMIT Imaging’s CFT technology is used today, from pharmacokinetics to therapy development.
Drug development & delivery
Whole-body biodistribution of compounds and carriers, on- and off-target.
Oncology & immunotherapy
Tumour targeting and immune response visualised in anatomical context.
Gene & cell therapy
Tracking delivery and expression of gene and cell based therapeutics.
Neuroscience
High-resolution fluorescence imaging of the intact CNS.
Antibody-drug conjugates
Distribution of ADCs from organ level down to fine structures.
Your partner for Xerra in Europe.
Application-first advice
We start with your research question and assess openly whether CFT is the right fit before you invest.
Local European partner
Quotation, delivery and coordination handled from Germany: one contact instead of overseas time zones.
Installation & training
We coordinate installation and onboarding with EMIT Imaging, so your team gets productive quickly.
Support after the sale
One contact for service and support, long after the system is installed.
Let's find the right path.
Whether you are evaluating a system for your lab or looking for a distribution partner in Europe, we reply personally and quickly.